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filingDate 2002-05-20^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2006-07-04^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1ad9e6ae0144930d8608e322e9a6668
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publicationDate 2006-07-04^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-7070780-B2
titleOfInvention Treatment of demyelinating autoimmune disease with ordered peptides
abstract Compositions and methods are provided for the treatment of demyelinating autoimmune disease. Therapeutic doses are administered of an ordered peptide comprising a repeated motif {SEQ ID NO: 1} [ 1 E 2 Y 3 Y 4 K] n , where n is from 2 to 6. Some specific peptides of interest include those having the sequence {SEQ ID NO:4} EYYKEYYKEYYK. The peptide may consist only of the ordered repeats, or may be extended at either termini by the addition of other amino acid residues. For therapy, the peptides may be administered topically or parenterally, e.g. by injection at a particular site, including subcutaneously, intraperitoneally, intravascularly, or the like or transdermally, as by electrotransport. In a preferred embodiment, subcutaneous injection is used to deliver the peptide. The subject methods are used for prophylactic or therapeutic purposes. The compositions of the invention may also contain other therapeutically active agents, e.g. immunosuppressants, β-interferon, steroids, etc.
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5F028
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6140
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA0A075DVI9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ142S4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8Y014
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5XAK4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5HWI6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA3PBP3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ81HW6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA0PPP5

Showing number of triples: 1 to 630 of 630.