| abstract |
Substituted heterocyclic derivatives are provided which have the structure n nwherein Z 1 is (CH 2 ) q or C═O;n Z 2 is (CH 2 ) p or C═O; D is —CH═ or C═O or (CH 2 ) m where m is 0, 1, 2 or 3; n=0, 1 or 2; p=1 or 2; q=0, 1 or 2; Q is C or N; X is CH or N; X 2 is C, N, O or S; X 3 is C, N, O or S; X 4 is C, N, O or S; X 5 is C, N, O or S; X 6 is C, N, O or S;n nprovided that at least one of X 2 , X 3 , X 4 , X 5 and X 6 is N; and at least one of X 2 , X 3 , X 4 , X 5 and X 6 is C;n A, B, R 1 , R 2 , R 2a , R 2b , R 4 , R 3 , E, Z and Y are as defined herein. n In addition, a method is provided for treating diabetes, Type 2 diabetes, insulin resistance, hyperglycemia, hyperinsulinemia, elevated blood levels of fatty acids or glycerol, hyperlipidemia, obesity, hypertriglyceridemia, Syndrome X, or atherosclerosis, wherein the substituted heterocyclic derivatives are administered in a therapeutically effective amount to a patient. |