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filingDate 2000-12-15^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2007-12-04^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecc7b3e14a26eaa552d6a0ce5b16e605
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publicationDate 2007-12-04^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-7304151-B2
titleOfInvention Modified leukotoxin gene and protein
abstract The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably from Mannheimia haemolytica . The modified leukotoxin proteins are useful in vaccine compositions effective against Mannheimia haemolytica in animals.
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