| abstract |
One object of the present invention is to provide a drug that is effective in treatments for and prevention of psychiatric disorders and in treatments for and prevention of neurological diseases, inhibiting a Group II metabotropic glutamate receptor. n The object is solved by a 2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative represented by formula [I]: n n(wherein R 1 and R 2 are the same or different, and each represents a hydrogen atom, C 1-10 alkyl group, etc; X represents a hydrogen atom or a fluorine atom; and Y represents an amino group, —SR 3 , —S(O) n R 7 , —SCHR 3 R 4 , —S(O) n CHR 3 R 4 , —NHCHR 3 R 4 , —N(CHR 3 R 4 )(CHR 5 R 6 ), —NHCOR 3 or —OCOR 7 ), a pharmaceutically acceptable salt thereof, or a hydrate thereof and so on. |