| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a01d7935508cbe002beb151d4efde669 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-23046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6421
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-8142 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
1999-12-24^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2008-11-25^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4de9f1e38517129764792dc57c1aa920
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d532becd6be6c421e5896e464209fe3b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd2c2b9d7f4b809ff9b83f9eab61bf1b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c25a9ee17489dd316227abe8444256b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_608256fc8419d2d5417858d1c2cc5227
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_384cc792b59e10090d1ee6e913b8827e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae895a9434129fd68d6d5af5a28bac46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fc90c43c58ae07b6402f45a47891f3e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7caaf11084eb0d559b1c1959cc0b7100
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63d2ee79d3431cf9f187fac969b41958
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e7f074461f0c2a9d5d0b01ad957757a |
| publicationDate |
2008-11-25^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7456007-B1 |
| titleOfInvention |
β-secretase enzyme compositions and methods |
| abstract |
Disclosed is an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (APP and APPsw) are also disclosed. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9453079-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11008403-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10882920-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11746160-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009075316-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9879094-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8772457-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009162883-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009144840-A1 |
| priorityDate |
1998-12-31^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |