http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7473535-B2

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filingDate 2002-08-20^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2009-01-06^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_361e209e239e09d14d17422d040f2c34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b0deac7ebff4f023a1f013602f63ae8
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publicationDate 2009-01-06^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-7473535-B2
titleOfInvention Chemical reagents and methods for detection and quantification of proteins in complex mixtures
abstract The invention provides a reagent comprising an affinity tag, a detectable moiety, a linker, an isotope tag and a reactive group. The invention also provides methods of using a reagent of the invention. The methods can be used to label a polypeptide in a sample by contacting a sample with a reagent of the invention under conditions allowing the reactive group to bind to one or more polypeptides in the sample. The invention additionally provides methods of isolating, identifying and quantifying a polypeptide in a sample. The invention further provides methods of diagnosing a disease using a reagent of the invention.
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