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filingDate 2004-10-28^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2009-06-02^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-7541447-B2
titleOfInvention Process for the preparation of an improved Brucella strain plasmid to develop the strain and the vaccine comprising the said strain
abstract A Brucella bacterium is modified by partial or complete deletion of the pgm gene, rendering the bacterium incapable of synthesizing a key enzyme in the metabolism of bacterial sugars. A live vaccine for immunization, prophylaxis or treatment of brucellosis comprises such a bacterium, either lyophilized or in a pharmaceutical vehicle. Nucleotide sequence fragments having the aforementioned deletion are disclosed, with methods for making them.
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