| abstract |
The present invention pertains to certain 6-carboaryloxy-pyrazin-2-yl-carboaryl-amines of the following formula, and pharmaceutically acceptable salts thereof, which, inter alia, inhibit RAF (e.g., B-RAF) activity, inhibit cell proliferation, treat cancer, etc., wherein Q is independently —N═; R P3 is independently a group of the formula -J 1 -L 1 -Z; -J 1 L 1 -Z is independently —NH—Z; Z is independently C 6-14 carboaryl and is independently unsubstituted or substituted; R P2 is independently —H; R P5 is independently a group of the formula —W—Y; W is independently —O—; Y is independently C 6-14 carboaryl and is independently unsubstituted or substituted; and R P6 is independently —H. The present invention also pertains to pharmaceutical compositions comprising such compounds. |