| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcff13f8573db698307f919e6385d5c4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16643
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2842
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-50 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1016
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-695
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-9486 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 |
| filingDate |
2006-06-01^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-11-02^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20f77e2315ad29e4333c2c7b3ba1d2b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6652fc2d18257f0ddf152b8179391879
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_057877cf3ef01323cc3637c7539175bf |
| publicationDate |
2010-11-02^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7825231-B2 |
| titleOfInvention |
Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy |
| abstract |
The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GFP)) all in operable linkage and under control of a promoter. Where the encoded precursor of a carboxy-amidated peptide is an agonist for an opioid receptor, the invention further provides a method of treating neuropathic pain by administering the gene transfer vector comprising such an expression cassette to a patient. The invention also provides a method for detecting a peptide having a desired effect comprising introducing a library of DNA sequences encoding one or more precursors of carboxy-amidated peptides into host cells; expressing the carboxy-amidated peptides encoded in the library to provide expression products; and screening from the polypeptide expression products for the desired effect. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846889-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011112174-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011112175-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10160959-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8003622-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10851354-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9580699-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8802957-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012041759-A1 |
| priorityDate |
2005-06-01^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |