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filingDate 2007-04-05^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2010-11-23^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-7838239-B2
titleOfInvention Methods regarding enhanced T-cell receptor-mediated tumor necrosis factor superfamily mRNA expression in peripheral blood leukocytes in patients with crohn's disease
abstract A method is disclosed for determining whether a human having Crohn's disease is likely to respond to a therapy targeting a TNFSF member or a cytokine by measuring the level of certain mRNAs in response to a stimulus. A method of evaluating the effectiveness of a Crohn's disease therapy in a human is also disclosed. Furthermore, a method of screening compounds for use in the treatment of Crohn's disease is disclosed. A method of monitoring the disease state over time in Crohn's disease patients is also disclosed.
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