| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6082ba4c6cd1a9b22570769b271fedd9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1aa877e508ad0f3a2ed38b5c6157f444
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fedda270d5b7c1e4ed273cb03aa73f4f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5047
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-243
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-241 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-40 |
| filingDate |
2009-07-09^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-11-22^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba63c8a1f1d0050a88df93e6f5c2be1f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63cf62d4f18c242cea165166d97ba065 |
| publicationDate |
2011-11-22^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8062637-B2 |
| titleOfInvention |
Methods of ameliorating inflammatory disease using an uPA antagonist |
| abstract |
The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9908944-B2 |
| priorityDate |
2000-05-08^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |