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filingDate 2005-03-04^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2012-01-03^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2012-01-03^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8088916-B2
titleOfInvention Hyaluronic acid-methotrexate conjugate
abstract An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. n There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.
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