| abstract |
The invention relates to derivatives and metabolites of ambrisentan, including compounds of general Formula (I) n nor salts, hydrates, solvates, racemates, or optical isomers thereof, wherein R 1 is —OH or —OCH 3 ; R 2 is —H, lower alkyl (e.g. C 1 -C 4 alkyl) or glycosidyl; and R 3 and R 4 are independently —CH 3 , —C(O)H or —CH 2 OR 6 , wherein R 6 is —H or a hydrocarbyl group having 1 to 20 carbon atoms. |