http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8242251-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3ef255a9be592563ce6cc21f37ec8d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e41651508566f0385833e1ba14a21ffd http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40453c2c360efe529cba10072ed2dfc1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-80 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-0066 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6816 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B55-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-0016 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09B23-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 |
| filingDate | 2011-02-02^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-08-14^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e927f872d7942ad13ace299e90553d05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2a2b3b640a956ad1608ea95a6759f05 |
| publicationDate | 2012-08-14^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8242251-B2 |
| titleOfInvention | Unsymmetrical cyanine dimer compounds and their application |
| abstract | Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two unsymmetrical cyanine monomer moieties, which may be the same or different, that are covalently attached by a linker comprising at least one aromatic, heteroaromatic, cyclic or heterocyclic moiety comprising 3-20 non-hydrogen atoms selected from the group consisting of O, N, S, P and C. The linker may be rigid, relatively flexible or some degree thereof. The unsymmetrical cyanine monomer moieties comprise a substituted or unsubstituted benzazolium moiety and a substituted or unsubstituted pyridinium or quinolinium moiety that is connected by a methine bridge that is monomethine, trimethine or pentamethine. The linkers form the cyanine dimer compounds by attaching to the pyridinium or quinolinium moiety of the monomer moieties. The present nucleic acid reporter molecules find utility in forming a nucleic acid-reporter molecule complex and detecting the nucleic acid. In particular, present nucleic acid reporter molecules with a rigid linker and monomer moieties with a monomethine bridge find utility in detecting RNA in the presence of DNA. |
| priorityDate | 2003-07-31^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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