| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aac4a747e60a2949ac458ccdbb76fdea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7498a755446e3a1e93a1f100dd7302e8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2250-0068
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-91 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F216-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G63-91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09D133-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-0077
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-74 |
| filingDate |
2007-04-30^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-02-26^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72bf54b000d2c99d2dae0809b6230497 |
| publicationDate |
2013-02-26^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8383156-B2 |
| titleOfInvention |
Coating for a medical device having an anti-thrombotic conjugate |
| abstract |
Methods for making comb-type antithrombotic conjugate wherein substantially all side chains of water soluble poly(vinyl alcohol) (PVA) are extended by ring-opening polymerization to form a copolymer wherein substantially all terminals are conjugated to an antithrombotic molecule. In addition, a method is provided for applying a coating comprising a comb-type anti-thrombotic conjugate to at least a portion of an implantable device to prevent or reduce the formation of thrombosis on the surface of the device. A first or sub-layer of the coating is prepared by mixing a polymeric material and a biologically active agent with a solvent, thereby forming a homogeneous solution. A second or outer layer comprising a comb-type anti-thrombotic conjugate may be applied over the inner drug-containing layers using, for example, a dip coating or spray coating process. Alternatively the comb-type antithrombotic conjugate may be used as a matrix material to encapsulate a pharmaceutical agent to form microspheres or nanospheres before depositing the microspheres or nanospheres onto a medical device. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10639085-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10285692-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11026729-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017055985-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9861410-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10569071-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8968765-B2 |
| priorityDate |
2007-04-30^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |