http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8383583-B2

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
filingDate 2008-10-24^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-02-26^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b697f9bf001ff4d56b0cdfcad3c4086
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e9c3bbbdf67a9cf003366ccf34f331b
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publicationDate 2013-02-26^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8383583-B2
titleOfInvention Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
abstract The present invention relates to compounds of Formula I, II, or III, or pharmaceutically acceptable salts, esters, or prodrugs thereof: n nwhich inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.
priorityDate 2007-10-26^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226394090
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID10044
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID636077
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID11126874
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP29098
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID128642623
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID14179013
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID127380804
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID20562897
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419502606
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http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID3769791
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID127701992
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http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID55283
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP22678
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ97BJ8
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA2T3N5
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5ULT9
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http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226400251

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