http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8518954-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29e6e822cbfd4f0d07c825b775c1d9dc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D475-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D475-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-90 |
| filingDate | 2010-06-08^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-08-27^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8bcd6441bf4d100d478ab8e1746c3b1 |
| publicationDate | 2013-08-27^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8518954-B2 |
| titleOfInvention | Inhibitors of folic acid-dependent enzymes |
| abstract | The invention relates to compounds of the formula I, or pharmaceutically acceptable salts thereof: n n n n n n n n n n n n wherein: n Z=O or S; n n=1-3; n R 3 =—CO 2 R 8 , —C(O)SR 8 , —C(O)NHR 8 , —C(S)OR 8 , —C(S)SR 8 , —C(S)NHR 8 , —C(NH)SR 8 or —C(NH)NHR 8 ,n wherein R 8 is —H or alkyl; n n R 4 =—H, —CH 2 R 5 or —CH 2 CH 2 R 5 ,n wherein R 5 independently has one of the meanings of R 3 ; n n B=—NR 2 —, —CH 2 NR 2 —, —CH 2 CH 2 NR 2 —, —CH 2 CHR 7 — or —CH 2 O—,n wherein R 2 is H or a C 1-3 alkyl, alkenyl or alkynyl group, and R 7 is H or a C 1-3 alkyl or alkoxy group; n n A= n n n n n nwherein R 1 =—NH 2 or —OH, and C and D are each, independently, a 5- or 6-membered, substituted or unsubstituted, aromatic or non-aromatic ring which may also contain one or more heteroatoms, and C is connected to group B in any available position. |
| priorityDate | 2005-08-17^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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