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filingDate 2011-10-06^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-12-03^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2013-12-03^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8597645-B2
titleOfInvention Cancer treatment with endothelin receptor antagonists
abstract The present invention relates to therapeutic protocols and pharmaceutical compositions designed to treat and prevent cancer. More specifically, the present invention relates to a novel method of treating cancer using antagonists to the endothelin B receptor (ETB) or inactive mimic forms of endothelin-1. The pharmaceutical compositions of the invention are capable of selectively inhibiting the early events associated with the development of cancer. The present invention further relates to screening assays to identify compounds which inhibit ETB activation.
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