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filingDate 2011-01-19^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2014-07-15^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8778336-B2
titleOfInvention Stabilized proteases that have been immobilized and further crosslinked for use in skin care
abstract Disclosed is an invention which relates to synthesizing immobilized and crosslinked proteases derived from plants for use as skin care agents. The resulting stabilized protease will minimally penetrate the skin because of its immobilized nature. It will retain activity because of its crosslinked nature and, in certain embodiments, due to its stabilization via physical additives. The present invention relates in particular to a linked papain product used in topical skin applications.
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