http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8785619-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7ab7cf39d1e9e75496dec2e09d8bf21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bca41eda70a68a5dba594ff409e12c3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e104f25c20ba5d0c81f2f69a2feb8bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42a709c6bc5177d4766767bbe25b3c14 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
| filingDate | 2004-12-20^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-07-22^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c1c1cd2941668a44b2f479c14fc3ca1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efce10c307f3959779c53debd86417f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0852e3606c6e689006a4c51b00998a6 |
| publicationDate | 2014-07-22^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8785619-B1 |
| titleOfInvention | Nucleosides and oligonucleotides for studies on reversal of cytotoxic and mutagenic damage of DNA potential diagnostics tools |
| abstract | This invention relates to n-alkylated synthetic nucleosides and phosphoramidites of high regio-specific purity and stability and for selective deprotection of the protecting group in oligonucleotides for the purpose of synthesis of high purity selectively n-alkylated sequence specific DNA and RNA. Such oligonucleotides are useful for study of mechanism of cytotoxic and mutagenic DNA damage, detection and reversal of cellular cytotoxic and mutagenic damages that occurs from the incorporation of methylated nucleosides, the corresponding phosphates and triphosphates and their precursors, via de novo DNA synthesis. The reagents could be extremely valuable tools as diagnostics and mutagenic reversal reagents. The present invention describes N-1-nitrogen alkylated purine and N-3 nitrogen alkylated pyrimidines with appropriate nucleobase amino protection, which are selectively deprotected with minimal migration of the alkyl substituent under the condition which are required for synthesizing high purity regiospecific N-1 and N-3 nitrogen alkylated oligonucleotides. A novel process has been developed to synthesize N-3 nitrogen alkylated cytidine. |
| priorityDate | 2003-12-20^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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