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filingDate 2012-04-27^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2014-09-02^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8822147-B2
titleOfInvention Sequential analysis of biological samples
abstract Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.
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