http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8951940-B2

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filingDate 2011-03-16^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-02-10^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_477284010f9679109d2cac48d213bca9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0b41ed72b9f0486de574ae30f007875
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publicationDate 2015-02-10^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8951940-B2
titleOfInvention Solid-phase clonal amplification and related methods
abstract The present invention provides methods and compositions for analyzing nucleic acid sequences. In some aspects, the methods utilize clonal objects, such as DNA balls, that have been captured on beads. Using the methods described here, compositions are fabricated wherein a bead and one clonal object are affinity bound or hybridized to each other through an affinity binding patch or hybridization patch on the surface of the bead. The invention also provides a population of beads having affinity bound or hybridized clonal objects at a ratio of 1:1. The invention additionally provides methods for amplifying a target nucleic acid molecule utilizing the compositions described herein.
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