http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8957210-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69d51c96f3aca51126081701e9011002 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2012-11-28^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-02-17^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5df6c98deb87a5f8d467e9d74f6c362e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61d582ed27fd60ad371e6a30b9994111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eae35731b8fe3c646b80025c1dae058c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00508662e95e55cbe5fe686b3e2f1690 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0d8b089279445b37f593b1247abe0c9 |
| publicationDate | 2015-02-17^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8957210-B2 |
| titleOfInvention | Method for synthesizing 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-formamidine hydrochloride |
| abstract | The present invention relates to the field of chemical synthesis, and in particular to a method for synthesizing 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-formamidine hydrochloride, which is an important intermediate of Riociguat that is an anti-thromboembolic-disease medicine. The method is characterized in that: 3-iodo-1H-pyrazolo[3,4-b]pyridine is used as a raw material; the raw material is reacted with fluorobenzyl bromide to form a compound (10); the compound (10) is reacted with zinc cyanide to form a compound (6); the compound (6) is reacted with sodium methoxide, ammonium chloride, acetic acid and methanol to form a compound (8); and the compound (8) is reacted with chlorine hydride gas to form 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-formamidine hydrochloride. The method has the characteristics of cheap and readily available raw materials, high yield, mild reaction conditions and the like, and is a synthesis method having a large-scale preparation value. |
| priorityDate | 2011-12-12^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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