http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9017976-B2

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filingDate 2010-11-17^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-04-28^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_698a313e47a93e2a940175f80a485fb1
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publicationDate 2015-04-28^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9017976-B2
titleOfInvention Engineering microbes for efficient production of chemicals
abstract This present invention relates to production of chemicals from microorganisms that have been genetically engineered and metabolically evolved. Improvements in chemical production have been established, and particular mutations that lead to those improvements have been identified. Specific examples are given in the identification of mutations that occurred during the metabolic evolution of a bacterial strain genetically engineered to produce succinic acid. This present invention also provides a method for evaluating the industrial applicability of mutations that were selected during the metabolic evolution for increased succinic acid production. This present invention further provides microorganisms engineered to have mutations that are selected during metabolic evolution and contribute to improved production of succinic acid, other organic acids and other chemicals of commercial interest.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11685938-B2
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priorityDate 2009-11-18^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6093260
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID297
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0CZ47
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0BXA8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0CT06
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5FS18
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP56418
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3873020
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO08349
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA4TRK3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1WR02
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID11428
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5E2W4
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID1402
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID10898860
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID12416
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID309
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA4IRP9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5REV7
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID66671011
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9MNX5
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID69368
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP16142
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB4SLI5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ54XS2
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID643757
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC1EUT6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO27179
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID548
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ4WLN1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP17783
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8FTA8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB6I1V4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB2SH29
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC1CMZ0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA7FGP4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8FG47
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP09369
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB1KWP9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO30019
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID615
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC3PJJ2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6NH63
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7NKU9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5RPW7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO94038
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5RMH1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA4TM44
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB1KGG7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB9JCF5
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID1271
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO93918
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP11708
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID7167
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP82611
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1W9K7
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID303
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC1D087
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419516508
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO30853

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