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grantDate 2015-12-29^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc8e43c975cda9c206ebf4bd9000fcfe
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publicationDate 2015-12-29^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9220677-B2
titleOfInvention Methods and compositions for CNS delivery of iduronate-2-sulfatase
abstract The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
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