| abstract |
The present invention relates to ethynyl derivatives of formula I n n n n n n n n n n n n wherein n Y is N or CH n R 1 is fluoro or chloro n R 2 is hydrogen or methyl n or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. n n n n n It has now surprisingly been found that the compounds of general formula I are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrome, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD). |