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filingDate 2015-01-07^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2016-07-05^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3616c74a846b0884c8052b9007759a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e15550bd77936f494d4246f0c0f85c4e
publicationDate 2016-07-05^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9382543-B2
titleOfInvention Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1
abstract The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Pyrroline-5-carboxylate reductase 1 (PYCR1), in particular, by targeting natural antisense polynucleotides of Pyrroline-5-carboxylate reductase 1 (PYCR1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PYCR1.
priorityDate 2010-02-22^^<http://www.w3.org/2001/XMLSchema#date>
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO04016
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226424833
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP16278
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419530451
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5583
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419547251
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226424832
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226401135
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1A831
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226413306
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID78168
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8D4H3
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395976
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395486
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9TRY9
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395485
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226406329
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP23989
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226411402
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6GGJ5
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395985
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ53H96
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID9877416
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID508658
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID406936270
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7A0U1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9R0J8
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395977
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395512
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID19816131
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http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID6343933
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226396003
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID54688261
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID421330823
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http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID1977
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA0KQH4
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID3893
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP24131
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP48981
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6013
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http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226399566
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO66553
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http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID413823327
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419487268
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID221493
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ09129
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ17QJ7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ49XV0

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