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filingDate 2012-09-06^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2016-10-04^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_167d6162ea00c5e1bb1a14ade8a37496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0208ffd2ae81bec565bb12ffcc70b9e
publicationDate 2016-10-04^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9457042-B2
titleOfInvention Pharmaceutical combination comprising a CIP2A silencing agent for use in the treatment of a hyperproliferative disorder, preferably one with impaired p53 function
abstract The invention is based on a finding that silencing CIP2A (KI-AA1524) gene sensitizes cancer cells for apoptosis-inducing activity of certain small molecule chemotherapeutic agents. Thus, the invention is directed to a respective combination therapy, sensitization method and pharmaceutical compositions. The invention further relates to a method of selecting cancer therapy for a subject on the basis of CIP2A and p53 expression and/or protein activity in a sample obtained from said subject.
priorityDate 2011-09-06^^<http://www.w3.org/2001/XMLSchema#date>
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