http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9505759-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2015-10-28^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-11-29^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5834e0dfa99933ee4472e40521a78bf4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91f98ba598f1394d254386dec72045f1 |
| publicationDate | 2016-11-29^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-9505759-B2 |
| titleOfInvention | Pd-catalyzed coupling of pyrazole amides |
| abstract | A novel process for the preparation of imidazo[1,2-a]pyridine compounds of the formula n n n n n n n n n n n n wherein n R 1 is C 1-4 -alkoxy or NR 4 R 5 whereinn R 4 and R 5 are independently hydrogen or C 1-4 -alkyl or R 4 and R 5 , together with the nitrogen atom to which they are attached, form a saturated 4- to 6-membered heterocyclic ring which may contain one further heteroatom selected from nitrogen or oxygen; n n R 2 is C 1-4 -alkyl, C 1-4 -alkoxycarbonyl, halogen, phenyl which is optionally substituted with C 1-4 -alkyl, C 1-4 -alkoxy or halogen or is NR 4 R 5 whereinn R 4 and R 5 are independently hydrogen or C 1-4 -alkyl or R 4 and R 5 , together with the nitrogen atom to which they are attached, form a saturated 4- to 6-membered heterocyclic ring which may contain one further heteroatom selected from nitrogen or oxygen; n n R 3 is C 1-4 -alkyl and n X is nitrogen or CH n is described. n n n n n The imidazo[1,2-a]pyridine compounds of the formula I are either precursors for active principles or active principles itself, acting as phosphodiesterase (PDE) inhibitors, particularly PDE10 inhibitors which have the potential to treat psychotic disorders like schizophrenia (Int. Patent Publication WO 2012/076430). |
| priorityDate | 2013-04-30^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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