| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ac55092bbe1f4ae3b2e12454bbc62af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2431af75bb711f346c924132e616efc7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0abde8be8ea93b5f005ab185dc30748d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2c36d6e52732619dbef9457745b206cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_683af08d913756b97cbad1e4b2a0a454
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_052f23c1d863449d689f012c82b4dd5f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d3b59dc6fa10a99dc54d14cbf9c58016 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39591
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate |
2012-04-27^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-04-25^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad35dd5c3f58be30d1142231101b1383
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e244dc725ccc11135c34e20665eff23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_221d703b6c4c85d062e82050b6f7cccf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18fc072775f4a51205b1a29f0fde319c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9af4d51d08e389ebb43eb76a81194634
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87fc85d66afe08ae1be8b475b2b8f4ca |
| publicationDate |
2017-04-25^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9631216-B2 |
| titleOfInvention |
Method for reducing heterogeneity of antibodies and a process of producing the antibodies thereof |
| abstract |
The present disclosure relates to a method of reducing heterogeneity in antibodies during culturing, wherein the heterogeneity is due to proportion of charge variant of the antibody. The disclosure also comprises a process of growing cells in a cell culture system that results in antibodies with the reduced heterogeneity. In one embodiment antibody heterogeneity is reduced by the addition of divalent transitional metal ions such as zinc (Zn 2+ ) to the cell culture medium. In another embodiment antibody heterogeneity is reduced by decreasing the osmolality of the cell culture medium. |
| priorityDate |
2011-04-29^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |