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grantDate 2017-10-17^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2017-10-17^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9791453-B2
titleOfInvention Methods for determining binding capability of target ligands with G protein-coupled receptors using translocation through nanochannels
abstract A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.
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