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filingDate 2010-07-06^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2017-12-26^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33081ac8623bc8574f5c8d495b0855f3
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publicationDate 2017-12-26^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9849173-B2
titleOfInvention Methods for preparing vesicles and formulations produced therefrom
abstract The present disclosure provides methods for preparing vesicles. In some embodiments, the methods involve providing a molten mixture of vesicle forming lipids and then adding the molten mixture to an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. In other embodiments, the methods involve providing a lyophilized lipid product and rehydrating the lyophilized lipid product with an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. The lyophilized lipid product is prepared by melting vesicle-forming lipids to produce a molten lipid mixture and then lyophilizing the molten lipid mixture. The present disclosure also provides antigen-containing vesicle formulations prepared using these methods. The present disclosure also provides kits that include a lyophilized lipid product in a first container and an aqueous solution comprising an antigen in a second container.
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http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID16186314
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID3005944
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1WM29
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5PJB2
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226487006
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP67970
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA4QLT3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP67969
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID100270759
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9PRQ9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ07FI2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP04667
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP67968
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID171040
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226491170
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ05163
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6YK33
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP56766
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCF7D9G8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCH0ZNW5
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID611309
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA4QLJ4
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID11701
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP19799
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2ICQ7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7U4E4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8MKH2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP19795
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP67931
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP27406
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID21960575
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID281096
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP67930
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226486425
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP27405
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ91MA2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ85B27
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226409512
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID2113
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP35051
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226393712
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ75VQ4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6XV52
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP67923
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP27404
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID9544
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCH0ZG98
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ67214

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