| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_17fb61fc925d5f9433b20f8b496d7238 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5076
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-533
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-502
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6875
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6878 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N1-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-533
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2016-09-12^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-01-02^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd7ba730a1de3fd2c69603f7312e4679
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7056e82e98244327506291a8541b9c72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cc9a03d48965e7f0bf29685d023b653 |
| publicationDate |
2018-01-02^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9857358-B2 |
| titleOfInvention |
Simplified nuclei analysis platform and biomarker matrix that supports genotoxic mode of action determinations |
| abstract |
The present invention relates a simple method for evaluating free eukaryotic cell nuclei for biomarkers of DNA damage and/or transcription factor activation, activity, or expression levels and/or epigenetic modifications to chromatin or chromatin-associated factors. The invention also teaches useful strategies for combining nuclear biomarkers into a matrix of endpoints that are capable of elucidating genotoxicants' primary mode of DNA-damaging activity. Kits for conducting methods according to the invention are also described. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018003720-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11016101-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10809268-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021132081-A1 |
| priorityDate |
2013-03-09^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |