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filingDate 2015-05-28^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2018-01-09^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01e19d42e7979e6d5498c1518a350517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8312576bc32dca0de47ef4e760e5dff
publicationDate 2018-01-09^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9861348-B2
titleOfInvention Chitosan and polyethylene glycol copolymers and methods and devices for using same for sealing a vascular puncture
abstract A sealant is provided for sealing a puncture through tissue that comprises an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The first section comprises chitosan and at least one additional polymer. The second section may be formed from a solid mass of non-freeze-dried, non-cross-linked hydrogel precursors. The precursors are in an unreactive state until exposed to an aqueous physiological environment, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. The second section may further comprise chitosan. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
priorityDate 2014-05-29^^<http://www.w3.org/2001/XMLSchema#date>
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