| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c274f815ad553995d21a9939466190c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2522-101
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2537-164 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6858 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2014-06-26^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-01-30^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9536c3a5d04709ce9f4c591f99e8e215
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9cc07cff3fae1edcf8864f290a538e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_194f757e283b38bf1c31d86c98d7e433 |
| publicationDate |
2018-01-30^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9879315-B2 |
| titleOfInvention |
Direct, programmable detection of epigenetic DNA cytosine modifications using TAL effectors |
| abstract |
Methods for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of the cytosine residue of interest or (ii) an unmodified cytosine residue of interest, the methods making use of the capability of transcription-activator-like effector (TALE) proteins to preferentially bind with strong affinity to nucleic acid sequences containing non-modified cytosine residues or 5-methyl modified cytosine residues, and to bind, if at all, with only strongly reduced affinity to nucleic acid sequences containing 5-hydroxymethyl modified cytosine residues. The present invention further relates to respective uses of TALE proteins for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of the cytosine residue of interest or (ii) the unmodified cytosine residue of interest. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10508301-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10612076-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11459573-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021054030-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10443091-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11208683-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10731204-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10533213-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10465234-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10774373-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10767216-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10563248-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11072818-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11078529-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10793899-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11608518-B2 |
| priorityDate |
2013-06-26^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |