| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0221cfbb710aca0e7f791b87705949d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b818cb56b5588f63bb26b10609e8a7e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e83d93ed02bbd6159e99b5a7796e3686
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_107da901899c9d7c715763dbb22faa0a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1029 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-82 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-06 |
| filingDate |
1999-12-21^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7560160648a6432a9dd44585648efa0c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e14e7bf986d6617fe04eeaa2cbba899
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_889e66d840d72fba505cef48eb3c48fc |
| publicationDate |
2000-09-14^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0037671-A3 |
| titleOfInvention |
Improved in vivo production of cephalosporins |
| abstract |
The present invention discloses a process for the production of 7-amino cephalosporanic acid (7-ACA) or a derivative thereof comprising the steps of fermenting a P. chrysogenum strain being transformed with an expression construct comprising a nucleotide sequence encoding expandase, hydroxylase and acetyltransferase activity in the presence of a suitable acyl side chain precursor, or a salt or ester thereof, such that an N-acylated 7-ACA compound is produced, N-deacylating the thus produced N-acylated 7-ACA compound and, optionally, acylating the free amino group and/or substituting the 3' acetate group with a side chain suitable to form a cephalosporin antibiotic, characterised in that the nucleotide sequence encoding the acetyltransferase is derived from Acremonium chrysogenum and starts at the second ATG of the open reading frame as present in said nucleotide sequence. |
| priorityDate |
1998-12-22^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |