| abstract |
Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of general formula (I), wherein Ar is aryl and heteroaryl; L is -C(O)N(Q)CH2-, or -CR?10R11OCR12R13¿-; Q is hydrido, -(CH¿2?)mCO2H and -(CH2)mCO2CH3, m is 1, 2, 3, and 4; R1, R?2, R9, R10, R11, R12 and R13¿ are hydrido or lower alkyl; wherein Het is a heterocyclic moiety, the inhibitors are suitable for use as antimicrobial agents. |