| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_60d2134a44f2b4765a9a1a36828c1d8c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e4506131cb8af659ad8fb3cac44095e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-0005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L2-18 |
| filingDate |
2002-05-16^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cf7bab4d014584f0be2d4a38ccb0bab |
| publicationDate |
2002-11-21^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-02092014-A2 |
| titleOfInvention |
Destruction of prions using vibriolysin or variants thereof |
| abstract |
The present invention provides a method of reducing the activity of prions using vibriolysin or variants thereof. Vibriolysin-containing solutions are used to sanitize prion-contaminated facilities and instruments and decontaminate food products and bilogical tissues. The present invention provides a method of treating prion-related disease in animals and humans, comprising the administration of a formulation of vibriolysin or a variant thereof together with a pharmaceutically acceptable carrier. Such novel formulations are engineered to track the natual path of the prion from cells where the prions accululate in the preclinical stage into neuronal cells and the brain at the advaced stage of the disease. The present invention provides methods and formulations that encompasses natural and recombinant vibriolysins and variants thereof with enhanced ability to access prion target cells, and with enzyme activity capable of being regulated by specific conditions, such as pH range or enzymatic cleavage. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2394663-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10646571-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3791862-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3808338-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10179172-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015038818-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11471479-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2394663-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007522822-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10821183-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10821184-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10849977-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8293174-B2 |
| priorityDate |
2001-05-16^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |