http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0248133-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8153c4f24b5bb392c7bec09c1a5ebd81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e78517965279f2376588a3546ade5280 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 |
| filingDate | 2001-12-11^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_606cc2d9745c1ee6e7d276c09ee3dfc5 |
| publicationDate | 2002-11-14^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-0248133-A3 |
| titleOfInvention | A process for the preparation of citalopram |
| abstract | A process for the preparation of Citalopram comprising the transformation of a compound of formula (VII), wherein R is C1-C4 alkyl. Compound (VII) is reacted in sequence with a Grignard reagent of a 4-halo fluorobenzene and a Grignard reagent of a 3-halo-N,N-dimethylpropylamine, respectively, giving a compound of formula (V), wherein R is as defined above. (V) Is hydrolysed to a compound of formula (IV), which is converted to a 5-oxime (III) by means of hydroxylamine, submitted to cyclization and converted to the corresponding 5-cyano derivative, i.e. Citalopram. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8440822-B2 |
| priorityDate | 2000-12-12^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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