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filingDate 2002-12-16^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5374fdaae1d04ff205b38d38316287eb
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publicationDate 2003-06-26^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-03051895-A1
titleOfInvention Processes for preparation of sulphostin and its analogues or intermediates thereof
abstract A process for preparation of compounds represented by the general formula (5): (5) [wherein n is an integer of 0 to 3; and Y is an amino-protecting group], which comprises making a silylating agent act on a compound represented by the general formula (3): (3) and then reacting the resulting compound with P(=O)T3 (wherein T is halogeno) and ammonia successively; and a process for preparation of sulphostin or analogues thereof as represented by the general formula (8): (8) [wherein C&ast; and P&ast; each independently take S- or R -configuration], which comprises forming a diastereomeric salt by the use of an optically active amine and resolving this salt by fractional crystallization.
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