| abstract |
A class of 1-phenylimidazo[4,5-b]pyridine derivatives, optionally substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, are selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety, convulsions and cognitive disorders. |