| abstract |
Medicinal compositions containing compounds represented by the following general formula (I): wherein each symbol is as defined in the description; salts thereof, solvates thereof or prodrugs thereof as the active ingredient. The compounds represented by the general formula (I) are useful in preventing and/or treating various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis, etc.), immune diseases (treatment for autoimmune diseases, rejection in transplanted organ, immune suppression, psoriasis, multiple sclerosis, etc.), infection with human immunodeficiency virus (acquired immune deficiency syndrome, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), inhibiting ischemic reperfusion injury, acute respiratory distress, shock accompanying bacterial infection, diabetes, cancer metastasis and so on. |