| abstract |
The invention relates to novel pyrazole derivatives which are inhibitors of the transforming growth factor, ('TGF')-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ('ALK')-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway. |