| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d93a3fdd031e483c033ce2641aca024b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5fbdf0afa37eaeff57a11c3d710be981
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24955ae922dd004f7abc42e7a7a21129
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7b56f8e9a6b41d26bfb8f3da696c09d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_48da4554a0ab647a88dbf244ce20eff0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2730-10122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-07049 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 |
| filingDate |
2004-06-11^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91157a47d0b4ed717b251c4d7c0b6995
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f051faf129544e9a209160959fa654ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b619b8e9bcde9037faefb9d7220a665
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40aee5cd2e46e8a4a194213edf8738f2 |
| publicationDate |
2004-12-23^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2004111079-A1 |
| titleOfInvention |
Viral polymerase and modulation thereof |
| abstract |
The present invention provides the tertiary structure of a Hepatitis B Virus (HBV) polymerase reverse transcriptase (rt) domain from which a variant HBV polymerase mutations associated with resistance to or having reduced sensitivity to an anti-viral drug have been mapped. The present invention further provides methods of identifying, designing and/or modifying agents capable of modulating the functional activity of the HBV polymerase based on the atomic co-ordinates provided by the tertiary structure. The present invention still further provides a method of modulating HBV polymerase functional activity and agents useful for same. The agents identified in accordance with the method of the present invention are particularly useful inter alia in the treatment and/or prophylaxis of infection by an HBV resistant to or exhibiting reduced sensitivity to an anti-viral drug. The agents may also have utility as diagnostic agents such as to distinguish between resistance mutations. Furthermore, the present invention enables responses of particular potential anti-viral drugs to be predicted. In addition, new targets within the polymerase have been identified. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1874923-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1874923-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9701982-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101477700-B |
| priorityDate |
2003-06-13^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |