| abstract |
Compounds selected from: formula (I) where DRUG-OH, DRUG-COOH and DRUG-NH2 are biologically active compounds; each X is independently selected from -CH2COO- (glycolic acid moiety), -CH(CH3)COO- (lactic acid moiety), -CH2CH2OCH2COO- (dioxanone moiety), -CH2CH2CH2CH2CH2COO- (caprolactone moiety), -(CH2)yCOO-, where y is 2-4 or 6-24 and -( CH2CH2O)ZCH2COO-, where z is 2-24; each Y is independently selected from -COCH2O- (glycolic ester moiety), -COCH(CH3)O- (lactic ester moiety), -COCH2OCH2CH2O- (dioxanone ester moiety), -COCH2CH2CH2CH2CH2O- (caprolactone ester moiety), -CO(CH2)mO-, where m is 2-4 or 6-24 and -COCH2O(CH2CH2O)n- where n is between 2-24; R' is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; and p is 1-6. Multi-functional compounds and drug dimers, oligomers and polymers are also disclosed. |