| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adf056ae2a0cdf7a829b1c9adc4c1832
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_114e4423ec77cbc8dab9d0a98909704e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f3a8ebe3c0ba75e98f195798d9260f63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ad3bc75f8f16512eedf3945e1fb9481b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_985dd6d30c77006626e9b19eade33fc9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_702bd91330d20aeddbb3fe29a38855a6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9e1f3d0cffa8560fb727075120c215df
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d70ee365b8c0c18bf7960d7abeed08d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57407
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57488 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2008-02-07^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e9d33668e6023e63677707a9e56cb1a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e1aca8370744eae2212621d11a8a13e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a341bfe5ae2a83c588a7cec26151609
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99ce4fe94d58f067cd6a3e84b1637053
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be87c88f151dbde43c107851ab34847f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66568a3a0299c975744bd752fdbe8cc2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d88916482304205ff39072f5387d6d84 |
| publicationDate |
2009-05-28^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008099419-A9 |
| titleOfInvention |
Autoantibodies for protein antigens as markers for cancer of gingivo-buccal complex |
| abstract |
The present invention relates to identification of a set of proteins, which elicit an autoantibody response in patients with cancer of gingivo-buccal complex. Systematic comparisons of serum samples from clinically normal individuals and from patients with cancer of gingivo-buccal complex has revealed significant differences in the presence of autoantibodies in sera against cellular antigens present in a cancer cell line. The autoantibody response to a single or combination of these protein antigens serves as a novel marker and can be utilized for screening, early detection,, prognosis, and potential target for therapy. The invention also provides for the use of the identified protein antigens in immunoassays designed to detect the presence of serum antibodies to the specific protein antigens in sera from individuals that harbor such antibodies. The invention also relates to the use of the identified antigens as immunogens for stimulation of an immune response in patients expressing such protein antigens. The invention is demonstrated by way of example in which elevated levels of circulating antibodies reactive against tumor specific antigens were identified in sera derived from patients with cancer of gingivo-buccal complex. The utility of identified antigens for early detection is assessed by analysis of sera from patients with leukoplakia of gingivo-buccal complex. |
| priorityDate |
2007-02-14^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |