| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a583ac8ac8f8c952847026833ecda0ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c1ed9172be30413aa370d8589890799
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e13e4c13fe64996895413453879610c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_91e2cb26955bbd751109d3c35b48a395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_62924da566ff64c0088b4cdc3af46923 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2008-02-28^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac567c055fb2dc185b3f777ee113981e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5845829d1f511afe20e8ad3795dc899
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39e7ec0b1185a9fdff844e94c7445173
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78a4c3281b02f30bd386fdff6d8642d5 |
| publicationDate |
2008-09-12^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008109359-A1 |
| titleOfInvention |
Nucleic acid compounds for inhibiting pdgfr family gene expression and uses thereof |
| abstract |
The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing one or more PDGFR family gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to one or more PDGFR family mRNA. In addition, the meroduplex may have at least one uridine substituted with a 5-methyluridine or 2-thioribothymidine and optionally other modifications.Also provided are methods of decreasing expression of one or more PDGFR family gene in a cell or in a subject to treat one or more PDGFR family-related disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9074205-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015017138-A1 |
| priorityDate |
2007-03-02^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |