| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_62924da566ff64c0088b4cdc3af46923
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a583ac8ac8f8c952847026833ecda0ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e13e4c13fe64996895413453879610c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_91e2cb26955bbd751109d3c35b48a395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c1ed9172be30413aa370d8589890799 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 |
| filingDate |
2008-02-29^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78a4c3281b02f30bd386fdff6d8642d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5845829d1f511afe20e8ad3795dc899
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39e7ec0b1185a9fdff844e94c7445173
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac567c055fb2dc185b3f777ee113981e |
| publicationDate |
2008-09-12^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008109474-A1 |
| titleOfInvention |
Nucleic acid compounds for inhibiting fgf2 gene expression and uses thereof |
| abstract |
The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing FGF2 gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to an FGF2 mRNA. In addition, the meroduplex may have at least one uridine substituted with a 5-methyluridine, a nucleoside replaced with a locked nucleic acid, or optionally other modifications, and any combination thereof. Also provided are methods of decreasing expression of an FGF2 gene in a cell or in a subject to treat an FGF2-related disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9074205-B2 |
| priorityDate |
2007-03-02^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |