| abstract |
A combination composition comprising a mixture of two or more cyclodextrin derivative compositions is provided. A CD derivative composition has an average degree of substitution and comprises a distribution of CD derivative species differing in their individual degrees of substitution. The average degree of substitution of one CD derivative composition is higher than the average degree of substitution of the other CD derivative composition, and their average degrees of substitution differ by at least one. The resulting combination composition exhibits a monomodal, bimodal, trimodal or multi¬ modal distribution profile. One CD derivative composition can be present in excess or in approximately the same amount as the other CD derivative composition in the combination composition. The combination composition can be made by combining two or more previously prepared CD derivative compositions, by direct derivatization of an underivatized parent CD, or by further direct derivatization of a previously prepared CD derivative composition. The combination composition provides enhanced performance over one or both of the CD derivative compositions in dissolution, stabilization, taste- masking and/or binding of compounds. |