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filingDate 2008-11-05^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37f9ebbd1023ea9fec189a2562694ff1
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publicationDate 2009-05-14^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2009060122-A2
titleOfInvention Use of oligonucleotides with modified bases as antiviral agents
abstract 1The present invention relates to the use of oligonucleotides having modified nucleobases to inhibit gene expression and/or replication of viruses in a subject. The modified nucleobases may be mercapto-modified bases or hydroxy-modified nucleobases. It is contemplated that the oligonucleotides further comprise a nuclease complex which enhances anti-viral activity of the oligonucleotides.
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